![]() The cellular infiltration in the spinal cord displays T-helper cells, macrophages that produce cytokines that intensify the inflammatory process. Some studies support the invasion of the large myelinated nerve fibers by Treponema pallidum and subsequent neuronal degeneration. The pathogenesis of tabes dorsalis follows the pattern of syphilis elsewhere: a perivascular inflammatory response against the treponeme along with gummas (caseous necrosis in granulomata). Although cerebrospinal fluid (CSF) invasion often occurs early in syphilis, the clinical syndrome of tabes dorsalis, one of two manifestations of late neurosyphilis, usually occurs years, often two to three decades later. It may be accompanied by meningitis or meningomyelitis. It generally occurs in the late tertiary stage of syphilis, but early involvement is reported. Tabes dorsalis is a slowly progressive parenchymatous degenerative disease of the dorsal column and dorsal root of the spinal cord as a result of syphilis caused by infection with Treponema pallidum pallidum, one of three subspecies of Treponema pallidum that can cause sexually transmitted disease in humans. This activity can help professionals' understanding of tabes dorsalis and can augment the interprofessional effort in caring for these individuals who often require institutionalization with support by several specialties like neurology, urology, and, eventually, sometimes palliative care. The disease has a delayed and insidious onset resulting in ataxia, dementia, painful crises, and skin, joint, and bladder abnormalities. ![]() Although CSF invasion often occurs early in infection with Treponema pallidum, the clinical syndrome of tabes dorsalis usually occurs many years, even decades, later. Tabes generally occurs in the late tertiary stage of syphilis, but early involvement is reported. Tabes dorsalis, one of two manifestations of late neurosyphilis, is a slowly progressive parenchymatous degenerative disease of the dorsal column and dorsal root of the spinal cord as a result of infection with Treponema pallidum subspecies pallidum, one of three subspecies of Treponema pallidum that can cause sexually transmitted diseases in humans.
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